One Alpha: Full Drug Profile

One Alpha - General Information

One Alpha is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. One Alpha is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. One Alpha is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism. (PMID:17438884,17668216)

Pharmacology of One Alpha

Not Available

Additional information about One Alpha

Generic Name

Alfacalcidol

Synonyms

1alpha-hydroxycholecalciferol; 1alpha-hydroxyvitamin D3; 1-hydroxycholecalciferol

Drug Category

Bone Density Conservation Agents

Drug Type

Small Molecule; Nutraceutical; Approved

Other Brand Names containing Alfacalcidol

One Alpha; Alsiodol;

Dosage Forms of One Alpha

Capsule Oral

Chemical IUPAC Name

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

Chemical Formula

C27H44O2

Organisms Affected

Humans and other mammals